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MK-571 sodium

MK-571 sodium
MK-571 sodium (L-660711 sodium salt) is a selective, orally active antagonist of the CysLT1 receptor. MK-571 sodium is a multidrug resistance protein-2 (ABCC2, Mrp2) inhibitor used to demonstrate the role of Mrp2 in the cellular efflux of drugs, xenobiotics, and their conjugates. MK-571 sodium can inhibit the synthesis of K-4′-O-GlcA (19.7 μM). MK571 dose-dependently inhibits the intracellular biosynthesis of all flavonol sulphates and glucuronides by Caco-2 cells. MK-571 sodium significantly inhibits phase-2 conjugation of kaempferol by cell-free extracts of Caco-2, and production of kaempferol-4′-O-glucuronide was competitively inhibited. In addition to inhibiting MRP2, MK571 is a potent inhibitor of enterocyte phase-2 conjugation.
Catalog No. T3148Cas No. 115103-85-0
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Purity:98.69%
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MK-571 sodium

Purity: 98.69%
Catalog No. T3148Alias Verlukast sodium, Propanoic acid, MK-571 sodium salt, MK571, L-660711 sodium salt, L-660711 (sodium salt), L-660711Cas No. 115103-85-0

MK-571 sodium (L-660711 sodium salt) is a selective, orally active antagonist of the CysLT1 receptor. MK-571 sodium is a multidrug resistance protein-2 (ABCC2, Mrp2) inhibitor used to demonstrate the role of Mrp2 in the cellular efflux of drugs, xenobiotics, and their conjugates. MK-571 sodium can inhibit the synthesis of K-4′-O-GlcA (19.7 μM). MK571 dose-dependently inhibits the intracellular biosynthesis of all flavonol sulphates and glucuronides by Caco-2 cells. MK-571 sodium significantly inhibits phase-2 conjugation of kaempferol by cell-free extracts of Caco-2, and production of kaempferol-4′-O-glucuronide was competitively inhibited. In addition to inhibiting MRP2, MK571 is a potent inhibitor of enterocyte phase-2 conjugation.
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Pack SizePriceAvailabilityQuantity
5 mg$47In Stock
10 mg$77In Stock
25 mg$177In Stock
50 mg$317In Stock
100 mg$473In Stock
1 mL x 10 mM (in DMSO)$63In Stock
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Product Introduction

Bioactivity
Description
MK-571 sodium (L-660711 sodium salt) is a selective, orally active antagonist of the CysLT1 receptor. MK-571 sodium is a multidrug resistance protein-2 (ABCC2, Mrp2) inhibitor used to demonstrate the role of Mrp2 in the cellular efflux of drugs, xenobiotics, and their conjugates. MK-571 sodium can inhibit the synthesis of K-4′-O-GlcA (19.7 μM). MK571 dose-dependently inhibits the intracellular biosynthesis of all flavonol sulphates and glucuronides by Caco-2 cells. MK-571 sodium significantly inhibits phase-2 conjugation of kaempferol by cell-free extracts of Caco-2, and production of kaempferol-4′-O-glucuronide was competitively inhibited. In addition to inhibiting MRP2, MK571 is a potent inhibitor of enterocyte phase-2 conjugation.
Targets&IC50
LTD4:0.22 nM (Ki, In guinea pig lung), LTD4:2.1 nM (Ki, In human lung)
Cell Research
Cells were seeded onto 96 well plates at a concentration of 1×103 cells per well and incubated for 72 h at 37?C and 5% CO2 to allow MRP1 messenger RNA suppression to occur. Cells were then treated with either control media or one of three chemotherapy drugs temozolomide (150 µM), vincristine (100 nM), or etoposide (2 µM). Cells were then returned to the incubator for a further 72 h; after which time, Metylthiazol Tetrazolium (MTT) powder in PBS (50µl of 5 mg/ml) was added to each well. Cells were then incubated for a further 4 h after which all solution was removed and dimethyl sulfoxide (DMSO) was added. After 10 min incubation time at 37?C, absorbance was recorded at 570 nm wavelength and data was recorded and analyzed. Small molecule inhibitors MK571 (25 µM) and Reversan (15µM) were added 7 h prior to carrying out further drug treatment (temozolomide, vincristine or etoposide) or assay assessment (media change for proliferation and 2D-migration assays) (Only for Reference)
AliasVerlukast sodium, Propanoic acid, MK-571 sodium salt, MK571, L-660711 sodium salt, L-660711 (sodium salt), L-660711
Chemical Properties
Molecular Weight537.07
FormulaC26H27ClN2O3S2·Na
Cas No.115103-85-0
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
H2O: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 25.78 mg/mL (48 mM), Sonication and heating are recommended.
Ethanol: Insoluble
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.8620 mL9.3098 mL18.6195 mL93.0977 mL
5 mM0.3724 mL1.8620 mL3.7239 mL18.6195 mL
10 mM0.1862 mL0.9310 mL1.8620 mL9.3098 mL
20 mM0.0931 mL0.4655 mL0.9310 mL4.6549 mL

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